SR-9009 (Stenobolic) Driada Medical EU

Manufacturer: Driada Medical EU

SR-9009, widely known by its research designation Stenabolic, is a synthetic REV-ERB agonist. Originally developed to study circadian rhythm regulation, it is frequently classified as an "exercise mimetic" due to its ability to influence metabolic processes similarly to physical exertion.

Important Compliance Note: SR-9009 is an investigational compound. It is not approved for human consumption by the FDA and is currently on the World Anti-Doping Agency (WADA) Prohibited List (Category S4: Hormone and Metabolic Modulators).

Technical Specifications

Mechanism of Action

SR-9009 functions by binding to and activating the nuclear receptors $REV-ERB\alpha$ and $REV-ERB\beta$. These receptors play a critical role in regulating the body's circadian clock, lipid (fat) metabolism, and glucose handling.

By synthetically activating these pathways, SR-9009 induces a state of increased metabolic activity:

• Mitochondrial Biogenesis: Research indicates it increases the count and efficiency of mitochondria in skeletal muscle, leading to higher energy output.

• Circadian Regulation: It modulates the sleep-wake cycle and metabolic timing, potentially keeping metabolism elevated even during rest.

Potential Benefits (Based on Preclinical Research)

While human trials are lacking, animal studies and anecdotal reports suggest the following effects:

1. Enhanced Fat Oxidation: The compound promotes the utilization of stored body fat for fuel while regulating glucose levels, potentially leading to a leaner body composition.

2. "Exercise in a Pill": Subjects in animal studies showed drastically improved endurance and reduced fatigue without prior training, earning it the "exercise mimetic" title.

3. Increased Basal Metabolic Rate (BMR): It is theorized to increase caloric expenditure at rest by altering the body's metabolic set point.

4. Cardioprotective Potential: Early research suggests it may help reduce cardiac hypertrophy (heart enlargement) and aid in tissue repair, though this is not yet clinically proven in humans.

Administration Guidelines (Research & Anecdotal)

The following information reflects common reported protocols for research purposes and does not constitute medical advice.

• Standard Dosage: Users typically report dosages ranging from 10 mg to 30 mg per day.

• Dosing Frequency: SR-9009 is noted for having a very short half-life. To maintain stable blood concentration and receptor activation, the total daily dose is often split into 3 to 4 micro-doses (e.g., every 4 hours).

• Cycle Duration: Typical cycles last between 8 and 12 weeks.

• Timing: Many users administer a dose 20–30 minutes prior to exercise to maximize endurance benefits.

Safety Profile and Risks

The long-term safety of SR-9009 in humans has not been established.

• Oral Bioavailability: There is ongoing debate regarding the efficacy of oral SR-9009, with some data suggesting low absorption rates when swallowed.

• Unknown Adverse Effects: Because it alters fundamental cellular clocks, misuse could potentially disrupt natural sleep cycles or hormonal balance.

• Cardiac Concerns: While some data suggests cardioprotection, the manipulation of metabolic modulators always carries a theoretical risk of unforeseen cardiac stress.

Frequently Asked Questions (FAQ)

1. How does SR-9009 actually burn fat?

It acts as an agonist to the $REV-ERB$ protein. When activated, this protein signals the body to switch its fuel source, prioritizing fatty acid oxidation (burning fat) and glucose metabolism over storage.

2. Why is it called an "Exercise Mimetic"?

It earns this name because it triggers physiological changes usually seen only after vigorous training—specifically, the creation of new mitochondria (mitochondrial biogenesis) and increased oxidative capacity—without the subject actually exercising.

3. Is SR-9009 safe for athletes to use?

No. It is banned by WADA and most sporting organizations. furthermore, because it has not undergone human clinical trials, its safety profile (toxicity, organ stress, long-term side effects) is officially unknown.

4. Why do users take it multiple times a day?

The compound is metabolized very quickly by the body. Taking a single large dose would result in a spike followed by a rapid drop-off. Dividing the dose ensures that the $REV-ERB$ receptors remain activated consistently throughout the day.